Endoplasmic reticulum stress is involved in myocardial apoptosis of streptozocin-induced diabetic rats

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Involvement of Endoplasmic Reticulum Stress in Myocardial Apoptosis of Streptozocin-Induced Diabetic Rats

Apoptosis plays critical role in diabetic cardiomyopathy and endoplasmic reticulum stress (ERS) is one of intrinsic apoptosis pathways. For previous studies have shown that endoplasmic reticulum become swell in diabetic myocardium and ERS was involved in diabetes mellitus and heart failure, this study aimed to demonstrate whether ERS was induced in myocardium of streptozocin (STZ)-induced diabe...

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Mediators of endoplasmic reticulum stress-induced apoptosis.

The efficient functioning of the endoplasmic reticulum (ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ER transmembrane receptors detect the onset of ER stress and initiate the unfolded protein response (UPR) to restore normal ER function. If the stress is prolonged, or the ada...

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ژورنال

عنوان ژورنال: Journal of Endocrinology

سال: 2007

ISSN: 0022-0795,1479-6805

DOI: 10.1677/joe-07-0230